وٹامن بی 6 · pyridoxine, P5P
Weak evidence
Some evidence for anxiety at high doses — and high doses are exactly what damages nerves.
This is information, not medical advice. This page is information, not medical advice. Nothing here is a prescription, a diagnosis or a recommendation to take anything, and none of it replaces a doctor who knows your history. Supplements are not harmless because they are natural: they interact with prescription medicines, some are unsafe in pregnancy, and a few can cause real damage. Talk to a doctor or pharmacist before starting anything here, especially if you are pregnant, breastfeeding, under 18, have a liver, kidney or heart condition, or take any regular medication. Never stop a prescribed antidepressant to try a supplement instead.
A B vitamin used in building serotonin, dopamine and GABA. In meat, fish, chickpeas, bananas and potatoes.
One trial found high-dose B6 reduced anxiety somewhat, which drew a lot of headlines for a single small study. There is better-established use in premenstrual symptoms. For depression on its own the evidence is thin. Correcting a deficiency is reasonable; megadosing on the strength of one study is not.
The anxiety trial used around 100 mg daily for a month. Ordinary supplements contain a small fraction of that, and the ceiling matters more than the target here.
Recorded because a person who has decided to try something will find a number somewhere, and a forum's number is worse than a trial's. It is not a recommendation, and the right amount for you depends on things only a doctor who knows your history can weigh.
This is the B vitamin that causes harm. Sustained doses above roughly 50 to 100 mg daily can cause peripheral neuropathy - numbness, pins and needles, unsteadiness - which is sometimes permanent. Check how much is in every product you take, since B6 is added to many energy and PMS formulas and doses stack.
Cheap and widely sold, often inside B-complex and "nerve tonic" products. Read the label of everything you take at once.
Tell your doctor or pharmacist about everything else you take, prescription and herbal both. If you are pregnant, breastfeeding, under 18, or have a liver, kidney, heart or thyroid condition, ask first. And if what brought you here is that you have been feeling low or frightened for weeks, that deserves more than a supplement — ask us anything, anonymously, or talk to us on WhatsApp.