گلائسین ·
Weak evidence
Small sleep-quality evidence. Cheap, sweet-tasting and low risk.
This is information, not medical advice. This page is information, not medical advice. Nothing here is a prescription, a diagnosis or a recommendation to take anything, and none of it replaces a doctor who knows your history. Supplements are not harmless because they are natural: they interact with prescription medicines, some are unsafe in pregnancy, and a few can cause real damage. Talk to a doctor or pharmacist before starting anything here, especially if you are pregnant, breastfeeding, under 18, have a liver, kidney or heart condition, or take any regular medication. Never stop a prescribed antidepressant to try a supplement instead.
A simple amino acid the body makes itself, also a calming neurotransmitter in the spinal cord and brainstem.
A few small trials found glycine before bed improved sleep quality and next-day tiredness. There is little direct evidence in anxiety. Where it may help is indirectly, through sleep - which is not nothing when poor sleep is driving how you feel.
Sleep studies used 3 g about an hour before bed.
Recorded because a person who has decided to try something will find a number somewhere, and a forum's number is worse than a trial's. It is not a recommendation, and the right amount for you depends on things only a doctor who knows your history can weigh.
Generally very safe. Mild stomach upset at higher doses. Not enough data in pregnancy. Clozapine is one interaction to check with a pharmacist.
Sold as bulk powder rather than in pharmacies. Inexpensive.
Tell your doctor or pharmacist about everything else you take, prescription and herbal both. If you are pregnant, breastfeeding, under 18, or have a liver, kidney, heart or thyroid condition, ask first. And if what brought you here is that you have been feeling low or frightened for weeks, that deserves more than a supplement — ask us anything, anonymously, or talk to us on WhatsApp.